Dynamic regulation of miRNA expression in ordered stages of cellular development.

  title={Dynamic regulation of miRNA expression in ordered stages of cellular development.},
  author={Joel R Neilson and Grace X. Y. Zheng and Christopher B. Burge and Phillip A. Sharp},
  journal={Genes & development},
  volume={21 5},
Short RNA expression in several distinct stages of T-lymphocyte development was comprehensively profiled. The total number of microRNAs (miRNAs) expressed per cell at different stages of development varies over nearly an order of magnitude in parallel with changes in total cellular RNA content, suggesting that global miRNA levels are coregulated with the translational capacity of the cell. However, individual miRNAs were dynamically regulated during T-cell development, with at least one miRNA… CONTINUE READING
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