Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.

@article{Ohnuki2014DynamicRO,
  title={Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential.},
  author={Mari Ohnuki and Koji Tanabe and Kenta Sutou and Ito Teramoto and Yuka Sawamura and Megumi Narita and Michiko Nakamura and Yumie Tokunaga and Masahiro Nakamura and Akira Watanabe and Shinya Yamanaka and Kazutoshi Takahashi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 34},
  pages={12426-31}
}
Pluripotency can be induced in somatic cells by overexpressing transcription factors, including POU class 5 homeobox 1 (OCT3/4), sex determining region Y-box 2 (SOX2), Krüppel-like factor 4 (KLF4), and myelocytomatosis oncogene (c-MYC). However, some induced pluripotent stem cells (iPSCs) exhibit defective differentiation and inappropriate maintenance of pluripotency features. Here we show that dynamic regulation of human endogenous retroviruses (HERVs) is important in the reprogramming process… CONTINUE READING
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