Dynamic regulation of copper uptake and detoxification genes in Saccharomyces cerevisiae.

@article{Pea1998DynamicRO,
  title={Dynamic regulation of copper uptake and detoxification genes in Saccharomyces cerevisiae.},
  author={Margarita M. Rodr{\'i}guez de la Pe{\~n}a and Keith A Koch and Dennis J Thiele},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 5},
  pages={2514-23}
}
The essential yet toxic nature of copper demands tight regulation of the copper homeostatic machinery to ensure that sufficient copper is present in the cell to drive essential biochemical processes yet prevent the accumulation to toxic levels. In Saccharomyces cerevisiae, the nutritional copper sensor Mac1p regulates the copper-dependent expression of the high affinity Cu(I) uptake genes CTR1, CTR3, and FRE1, while the toxic copper sensor Ace1p regulates the transcriptional activation of the… CONTINUE READING

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