Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq

@article{Gan2010DynamicRO,
  title={Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq},
  author={Qiang Gan and Iouri Chepelev and Gang W. Wei and Lama Tarayrah and Kairong Cui and Keji Zhao and Xin Chen},
  journal={Cell Research},
  year={2010},
  volume={20},
  pages={763-783}
}
Both transcription and post-transcriptional processes, such as alternative splicing, play crucial roles in controlling developmental programs in metazoans. Recently emerged RNA-seq method has brought our understanding of eukaryotic transcriptomes to a new level, because it can resolve both gene expression level and alternative splicing events simultaneously. To gain a better understanding of cellular differentiation in gonads, we analyzed mRNA profiles from Drosophila testes and ovaries using… CONTINUE READING
Highly Cited
This paper has 484 citations. REVIEW CITATIONS