Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.

@article{Ingi1998DynamicRO,
  title={Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.},
  author={Tatsuya Ingi and Andrejs M Krumins and Peter Chidiac and Greg M. Brothers and Sooyoung E Chung and Bryan E. Snow and Carol A. Barnes and Anthony A. Lanahan and David P. Siderovski and Elliott M. Ross and Alfred G. Gilman and Paul F Worley},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 18},
  pages={7178-88}
}
Long-term neuronal plasticity is known to be dependent on rapid de novo synthesis of mRNA and protein, and recent studies provide insight into the molecules involved in this response. Here, we demonstrate that mRNA encoding a member of the regulator of G-protein signaling (RGS) family, RGS2, is rapidly induced in neurons of the hippocampus, cortex, and striatum in response to stimuli that evoke plasticity. Although several members of the RGS family are expressed in brain with discrete neuronal… CONTINUE READING
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