Dynamic regulation of NMDAR function in the adult brain by the stress hormone corticosterone

  title={Dynamic regulation of NMDAR function in the adult brain by the stress hormone corticosterone},
  author={Yiu Chung Tse and Rosemary C. Bagot and Tak Pan Wong},
  booktitle={Front. Cell. Neurosci.},
Stress and corticosteroids dynamically modulate the expression of synaptic plasticity at glutamatergic synapses in the developed brain. Together with alpha-amino-3-hydroxy-methyl-4-isoxazole propionic acid receptors (AMPAR), N-methyl-D-aspartate receptors (NMDAR) are critical mediators of synaptic function and are essential for the induction of many forms of synaptic plasticity. Regulation of NMDAR function by cortisol/corticosterone (CORT) may be fundamental to the effects of stress on… CONTINUE READING


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