Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver

@inproceedings{Schug2013DynamicRO,
  title={Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver},
  author={Jonathan Schug and Lindsay B. McKenna and Gabriel Walton and Nicholas J Hand and Sarmistha M Mukherjee and Kow Essuman and Zhongjie Shi and Yan Gao and Karen Markley and Momo Nakagawa and Vasumathi Kameswaran and Anastassios Vourekas and Joshua R Friedman and Klaus H. Kaestner and Linda E. Greenbaum},
  booktitle={BMC Genomics},
  year={2013}
}
Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs. miRNA recruitment to the RISC is highly dynamic, changing more than five-fold for several miRNAs. miRNA recruitment to the RISC did not correlate with changes… CONTINUE READING