Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.

@article{Hames2005DynamicRO,
  title={Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.},
  author={Rebecca S. Hames and Renarta E Crookes and Kees R. Straatman and Andreas Merdes and Michelle J. Hayes and Alison J. Faragher and Andrew M Fry},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 4},
  pages={
          1711-24
        }
}
Centrosomes undergo dramatic changes in composition and activity during cell cycle progression. Yet mechanisms involved in recruiting centrosomal proteins are poorly understood. Nek2 is a cell cycle-regulated protein kinase required for regulation of centrosome structure at the G2/M transition. Here, we have addressed the processes involved in trafficking of Nek2 to the centrosome of human adult cells. We find that Nek2 exists in small, highly dynamic cytoplasmic particles that move to and from… CONTINUE READING

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The role of the centrosome in cell cycle progression

  • A. M. Fry, R. S. Hames
  • In: Centrosomes in Development and Disease, ed. E…
  • 2004
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