Dynamic properties of nucleosomes during thermal and ATP-driven mobilization.

  title={Dynamic properties of nucleosomes during thermal and ATP-driven mobilization.},
  author={Andrew Flaus and Tom Owen-Hughes},
  journal={Molecular and cellular biology},
  volume={23 21},
The fundamental subunit of chromatin, the nucleosome, is not a static entity but can move along DNA via either thermal or enzyme-driven movements. Here we have monitored the movements of nucleosomes following deposition at well-defined locations on mouse mammary tumor virus promoter DNA. We found that the sites to which nucleosomes are deposited during chromatin assembly differ from those favored during thermal equilibration. Taking advantage of this, we were able to track the movement of… CONTINUE READING


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