Dynamic organization of splicing factors in adenovirus-infected cells.

  title={Dynamic organization of splicing factors in adenovirus-infected cells.},
  author={Eileen Bridge and D X Xia and Maria Carmo-Fonseca and Beatrice Cardinali and Angus I. Lamond and U. Pettersson},
  journal={Journal of virology},
  volume={69 1},
Adenovirus infection affects the nuclear distribution of host splicing factors. Late phase-infected cells contain discrete clusters of small nuclear ribonucleoproteins (snRNPs) that are separate from centers containing the viral 72-kilodalton DNA-binding protein (72K protein). In the present study, we demonstrate that these snRNP clusters also contain splicing factors from the SR protein family. We show that a previously described monoclonal antibody, 3C5, detects SR proteins. Furthermore, we… CONTINUE READING
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