Dynamic organization of chromatin assembly and transcription factories in living cells.

Abstract

The interphase nucleus is an active organelle involved in processing genetic information. In higher order eukaryotes, information control is compartmentalized - for example at the scale of inter-chromosome territories and nuclear bodies. Regulatory proteins, nuclear bodies and chromatin assembly are found to be highly dynamic within the nucleus of primary cells and through cellular differentiation programs. In this chapter we describe live-cell fluorescence based techniques and single particle tracking analysis, to probe the spatio-temporal dimension in nuclear function.

DOI: 10.1016/S0091-679X(10)98003-5

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@article{Sinha2010DynamicOO, title={Dynamic organization of chromatin assembly and transcription factories in living cells.}, author={Bidisha Sinha and Dipanjan Bhattacharya and Deepak Kumar Sinha and Shefali Talwar and Shovamayee Maharana and Soumya Sen Gupta and G. V. Shivashankar}, journal={Methods in cell biology}, year={2010}, volume={98}, pages={57-78} }