Dynamic optimization identifies optimal programmes for pathway regulation in prokaryotes.

@article{Bartl2013DynamicOI,
  title={Dynamic optimization identifies optimal programmes for pathway regulation in prokaryotes.},
  author={Martin Bartl and Martin K{\"o}tzing and Stefan Schuster and Pu Li and Christoph Kaleta},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={
          2243
        }
}
To survive in fluctuating environmental conditions, microorganisms must be able to quickly react to environmental challenges by upregulating the expression of genes encoding metabolic pathways. Here we show that protein abundance and protein synthesis capacity are key factors that determine the optimal strategy for the activation of a metabolic pathway. If protein abundance relative to protein synthesis capacity increases, the strategies shift from the simultaneous activation of all enzymes to… CONTINUE READING
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