Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein.

@article{Goley2006DynamicNA,
  title={Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein.},
  author={Erin D Goley and Taro Ohkawa and Joel Mancuso and Jeffrey B Woodruff and Joseph A D'Alessio and William Zacheus Cande and Loy E. Volkman and Matthew D Welch},
  journal={Science},
  year={2006},
  volume={314 5798},
  pages={464-7}
}
Diverse bacterial and viral pathogens induce actin polymerization in the cytoplasm of host cells to facilitate infection. Here, we describe a pathogenic mechanism for promoting dynamic actin assembly in the nucleus to enable viral replication. The baculovirus Autographa californica multiple nucleopolyhedrovirus induced nuclear actin polymerization by translocating the host actin-nucleating Arp2/3 complex into the nucleus, where it was activated by p78/83, a viral Wiskott-Aldrich syndrome… CONTINUE READING

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  • T. Ohkawa, A. R. Rowe, L. E. Volkman
  • Virol. 76,
  • 1228
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