Dynamic multidrug therapies for hiv: optimal and sti control approaches.

  title={Dynamic multidrug therapies for hiv: optimal and sti control approaches.},
  author={Benjamin M. Adams and H. T. Banks and Hee-Dae Kwon and H. T. Tran},
  journal={Mathematical biosciences and engineering : MBE},
  volume={1 2},
We formulate a dynamic mathematical model that describes the interaction of the immune system with the human immunodeficiency virus (HIV) and that permits drug "cocktail " therapies. We derive HIV therapeutic strategies by formulating and analyzing an optimal control problem using two types of dynamic treatments representing reverse transcriptase (RT) in hibitors and protease inhibitors (PIs). Continuous optimal therapies are found by solving the corresponding optimality systems. In addition… CONTINUE READING
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