Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development

@article{Sinclair2011DynamicMA,
  title={Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development},
  author={Duncan Sinclair and Maree J. Webster and Jenny Wong and Cynthia Shannon Weickert},
  journal={Molecular Psychiatry},
  year={2011},
  volume={16},
  pages={504-515}
}
The glucocorticoid receptor (GR) has a critical role in determining the brain's capacity to respond to stress, and has been implicated in the pathogenesis of psychiatric illness. We hypothesized that key changes in cortical GR occur during adolescence and young adulthood, at a time when individuals are at increased risk of developing schizophrenia, bipolar disorder and major depression. We investigated the mRNA and protein expression of GR in the dorsolateral prefrontal cortex across seven… CONTINUE READING