Dynamic modeling of cis-regulatory circuits and gene expression prediction via cross-gene identification

Abstract

Gene expression programs depend on recognition of cis elements in promoter region of target genes by transcription factors (TFs), but how TFs regulate gene expression via recognition of cis elements is still not clear. To study this issue, we define the cis-regulatory circuit of a gene as a system that consists of its cis elements and the interactions among… (More)
DOI: 10.1186/1471-2105-6-258

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