Dynamic modeling of Escherichia coli metabolic and regulatory systems for amino-acid production.


Our aim is to construct a practical dynamic-simulation system that can model the metabolic and regulatory processes involved in the production of primary metabolites, such as amino acids. We have simulated the production of glutamate by transient batch-cultivation using a model of Escherichia coli central metabolism. Kinetic data were used to produce both… (More)
DOI: 10.1016/j.jbiotec.2010.02.018


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