Dynamic mitral regurgitation. An important determinant of the hemodynamic response to load alterations and inotropic therapy in severe heart failure.

@article{Keren1989DynamicMR,
  title={Dynamic mitral regurgitation. An important determinant of the hemodynamic response to load alterations and inotropic therapy in severe heart failure.},
  author={Gad Keren and Stanley Katz and Joel A. Strom and Edmund H. Sonnenblick and Thierry H Lejemtel},
  journal={Circulation},
  year={1989},
  volume={80 2},
  pages={306-13}
}
Cardiac performance and mitral regurgitation were measured by Doppler echocardiography and right heart catheterization in 12 patients with severe congestive heart failure who performed isometric exercise during control and intravenous administration of dobutamine and nitroglycerin. During control isometric exercise, mitral regurgitant volume increased from 18 +/- 13 to 31 +/- 17 ml (p less than 0.01), while forward stroke volume, by both thermodilution and Doppler echocardiography… CONTINUE READING