Dynamic mechanisms determine functional residual capacity in mice, Mus musculus.

  title={Dynamic mechanisms determine functional residual capacity in mice, Mus musculus.},
  author={Allen Vinegar and E. E. Sinnett and David E. Leith},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  volume={46 5},
Awake mice (22.6--32.6 g) were anesthetized intravenously during head-out body plethysmography. One minute after pentobarbital sodium anesthesia, tidal volume had fallen from 0.28 +/- 0.04 to 0.14 +/- 0.02 ml and frequency from 181 +/- 20 to 142 +/- 8. Functional residual capacity (FRC) decreased by 0.10 +/- 0.02 ml. Expiratory flow-volume curves were linear, highly repeatable, and submaximal over substantial portions of expiration in awake and anesthetized mice; and expiration was interrupted… CONTINUE READING


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