Dynamic mechanism for initiation of ventricular fibrillation in vivo.

  title={Dynamic mechanism for initiation of ventricular fibrillation in vivo.},
  author={Anna R. M. Gelzer and Marcus L. Koller and Niels F. Otani and Jeffrey J. Fox and Michael W. Enyeart and Giles Hooker and Mark L. Riccio and Carlo Bartoli and Robert F. Gilmour},
  volume={118 11},
BACKGROUND Dynamically induced heterogeneities of repolarization may lead to wave-front destabilizations and initiation of ventricular fibrillation (VF). In a computer modeling study, we demonstrated that specific sequences of premature stimuli maximized dynamically induced spatial dispersion of refractoriness and predisposed the heart to the development of conduction block. The purpose of this study was to determine whether the computer model results pertained to the initiation of VF in dogs… CONTINUE READING