Dynamic measurements of cerebral pentose phosphate pathway activity in vivo using [1,6-13C2,6,6-2H2]glucose and microdialysis.

  title={Dynamic measurements of cerebral pentose phosphate pathway activity in vivo using [1,6-13C2,6,6-2H2]glucose and microdialysis.},
  author={Oded Ben-Yoseph and Dana M Camp and Terry E. Robinson and Brian D. Ross},
  journal={Journal of neurochemistry},
  volume={64 3},
Cerebral pentose phosphate pathway (PPP) activity has been linked to NADPH-dependent anabolic pathways, turnover of neurotransmitters, and protection from oxidative stress. Research on this potentially important pathway has been hampered, however, because measurement of regional cerebral PPP activity in vivo has not been possible. Our efforts to address this need focused on the use of a novel isotopically substituted glucose molecule, [1,6-13C2,6,6-2H2]glucose, in conjunction with microdialysis… CONTINUE READING
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Measurement of pentose phosphate pathway activity in a single incubation with, [1,6-"C2,6,6-=HZ] glucose

  • D RossB., B KingsleyP., O Ben-Yoseph
  • Biochem . J .
  • 1994

Comparison of rates of local cerebral glucose utilization determined with deoxyll-"CJglucose and deoxyl6-"CIglucose

  • H .Nakanishi, P. Melzer, P .Moulis, L Sokoloff
  • J . Neurochem .
  • 1992

The feasibility of repeated microdialysis for within subjects design experiments : studies on the mesostriatal dopamine system, in Microdialysis in the Neurosciences

  • E RobinsonT., D Camp
  • Techniques in the Behavioral and Neural Sciences,
  • 1991

Regulation of the pentose phosphate pathway in human astrocytes and gliomas

  • J LoreekD., J Galarraga, J VanderFeen, M PhangJ., H SmithB., J CumminsC.
  • Metab . Brain Dis
  • 1987

Cerebral glucose use measured with ["C]glucose

  • A HawkinsR., M MansA., W DavisD., R VinaJ., S HibbardL.
  • 1985

Determina - tion of carbon - 13 labeled lactate in blood by gas chromatography / mass spectrometry

  • S. Zubairu, S. HothersallJ., A. El-Hassan, P. McLean, L Greenbaum
  • Anal . Chem .
  • 1984

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