Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker.

@article{Engels2007DynamicIS,
  title={Dynamic intracellular survivin in oral squamous cell carcinoma: underlying molecular mechanism and potential as an early prognostic marker.},
  author={K. A. Engels and Shirley K. Knauer and Dirk Metzler and C Simf and O Struschka and Carolin Bier and Wolf Mann and Adorj{\'a}n Ferenc Kov{\'a}cs and Roland H. Stauber},
  journal={The Journal of pathology},
  year={2007},
  volume={211 5},
  pages={532-40}
}
Survivin functions as an apoptosis inhibitor and a regulator of cell division in many tumours. The intracellular localization of survivin in tumours has been suggested as a prognostic marker. However, current reports are inconsistent and the underlying molecular mechanisms are not understood. The present study has examined the localization and prognostic value of nuclear and cytoplasmic survivin in the pre-therapeutic biopsies from 71 oral and oropharyngeal squamous carcinoma (OSCC) patients… CONTINUE READING

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