Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways.

@article{Jardin2009DynamicIO,
  title={Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways.},
  author={Isaac Jardin and Luis Jes{\'u}s Villarreal G{\'o}mez and Gin{\'e}s M Salido and Juan Antonio Rosado},
  journal={The Biochemical journal},
  year={2009},
  volume={420 2},
  pages={
          267-76
        }
}
  • Isaac Jardin, Luis Jesús Villarreal Gómez, +1 author Juan Antonio Rosado
  • Published in The Biochemical journal 2009
  • Chemistry, Medicine
  • TRPC (canonical transient receptor potential) channel subunits have been shown to assemble into homo- or hetero-meric channel complexes, including different Ca2+-handling proteins, required for the activation of CCE (capacitative Ca2+ entry) or NCCE (non-CCE) pathways. In the present study we found evidence for the dynamic interaction between endogenously expressed hTRPC6 (human TRPC6) with either both Orai1 and STIM1 (stromal interaction molecule 1) or hTRPC3 to participate in CCE or NCCE… CONTINUE READING

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