Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants

@article{Barouch2005DynamicIR,
  title={Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants},
  author={Dan H Barouch and Jennifer Powers and Diana M. Truitt and Michael G. Kishko and Janelle C Arthur and Fred W. Peyerl and Marcelo J. Kuroda and Darci A. Gorgone and Michelle A. Lifton and Carol I. Lord and Vanessa M Hirsch and David C. Montefiori and Angela Carville and Keith G Mansfield and Kevin J. Kunstman and Steven M. Wolinsky and Norman L. Letvin},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={247-252}
}
Viral escape from cytotoxic T lymphocytes (CTLs) can undermine immune control of human immunodeficiency virus 1. It is therefore important to assess the stability of viral mutations in CTL epitopes after transmission to naive hosts. Here we demonstrate the persistence of mutations in a dominant CTL epitope after transmission of simian immunodeficiency virus variants to major histocompatibility complex–matched rhesus monkeys. Transient reversions to wild-type sequences occurred and elicited CTLs… CONTINUE READING

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