Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow.

@article{Milo2013DynamicIR,
  title={Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow.},
  author={Idan Milo and Anita Sapoznikov and Vyacheslav Kalchenko and Orna Tal and Rita Krauthgamer and Nico Van Rooijen and Diana Dudziak and Steffen Jung and Guy Shakhar},
  journal={Blood},
  year={2013},
  volume={122 2},
  pages={193-208}
}
The bone marrow (BM) hosts memory lymphocytes and supports secondary immune responses against blood-borne antigens, but it is unsettled whether primary responses occur there and which cells present the antigen. We used 2-photon microscopy in the BM of live mice to study these questions. Naïve CD8(+) T cells crawled rapidly at steady state but arrested immediately upon sensing antigenic peptides. Following infusion of soluble protein, various cell types were imaged ingesting the antigen, while… CONTINUE READING

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