Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

@article{Brown2003DynamicIO,
  title={Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation},
  author={Edward B. Brown and Trevor McKee and Emmanuelle diTomaso and Alain Pluen and Brian Seed and Yves Boucher and Rakesh K. Jain},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={796-800}
}
The content and structure of collagen is essential in governing the delivery of therapeutic molecules in tumors. Thus, simple histological staining of tumor tissue biopsies for collagen could be used to assess the accessibility of molecular therapeutics in tumors. Here we show that it is possible to optically image fibrillar collagen in tumors growing in mice using second-harmonic generation (SHG). Using this noninvasive technique, we estimated relative diffusive hindrance, quantified the… CONTINUE READING
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