Dynamic gain control of dopamine delivery in freely moving animals.

  title={Dynamic gain control of dopamine delivery in freely moving animals.},
  author={P. Read Montague and Samuel M. McClure and Philip Rupert Baldwin and Paul E. M. Phillips and Evgeny A. Budygin and Garret D. Stuber and Michaux R Kilpatrick and R Mark Wightman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 7},
Activity changes in a large subset of midbrain dopamine neurons fulfill numerous assumptions of learning theory by encoding a prediction error between actual and predicted reward. This computational interpretation of dopaminergic spike activity invites the important question of how changes in spike rate are translated into changes in dopamine delivery at target neural structures. Using electrochemical detection of rapid dopamine release in the striatum of freely moving rats, we established that… CONTINUE READING


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