Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke.

@article{Wu2012DynamicFC,
  title={Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke.},
  author={Ona Wu and Jie Lu and Joseph B. Mandeville and Yoshihiro Murata and Yasu Egi and Guangping Dai and John J. A. Marota and Izzuddin M Diwan and Rick M. Dijkhuizen and Kenneth K. Kwong and Eng H. Lo and Aneesh Bhim Singhal},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2012},
  volume={32 9},
  pages={1800-9}
}
Studies suggest that neuroprotective effects of normobaric oxygen (NBO) therapy in acute stroke are partly mediated by hemodynamic alterations. We investigated cerebral hemodynamic effects of repeated NBO exposures. Serial magnetic resonance imaging (MRI) was performed in Wistar rats subjected to focal ischemic stroke. Normobaric oxygen-induced functional cerebral blood volume (fCBV) responses were analyzed. All rats had diffusion-weighted MRI (DWI) lesions within larger perfusion deficits… CONTINUE READING

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