Dynamic force spectroscopy of photoswitch-modified DNA.

Abstract

We apply a combination of photoswitch-modified DNA and AFM-based pulling measurements to study the force-induced melting of double-stranded DNA in the unzipping geometry. We measure the differences in peak rupture force for azobenzene-modified DNA, as the incorporated azobenzenes are photoswitched reversibly between the trans and the cis form. Fitting our… (More)
DOI: 10.1021/nn406334b

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