• Corpus ID: 252355029

Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

  title={Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration},
  author={W. Duncan Martinson and Rebecca McLennan and Jessica M. Teddy and Mary Cathleen McKinney and Lance A. Davidson and Ruth E. Baker and Helen M. Byrne and Paul M. Kulesa and Philip K. Maini},
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM) component fibronectin during the migration of loosely connected neural crest cells (NCCs) lead us to hypothesize that NCC remodeling of an initially punctate ECM creates a scaffold for trailing cells, enabling them to form robust and coherent stream… 

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