Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV-1) gp120 CD4-binding site in a group of long term non progressor (LTNP) subjects

@article{Canducci2008DynamicFO,
  title={Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV-1) gp120 CD4-binding site in a group of long term non progressor (LTNP) subjects},
  author={Filippo Canducci and Maria Chiara Marinozzi and Michela Sampaolo and Stefano B{\`e}rre and Patrizia Bagnarelli and Massimo Degano and Giulia Gallotta and Benedetta Mazzi and Philippe Lemey and Roberto Burioni and Massimo Clementi},
  journal={Retrovirology},
  year={2008},
  volume={6},
  pages={4 - 4}
}
The characteristics of intra-host human immunodeficiency virus type 1 (HIV-1) env evolution were evaluated in untreated HIV-1-infected subjects with different patterns of disease progression, including 2 normal progressor [NP], and 5 Long term non-progressor [LTNP] patients. High-resolution phylogenetic analysis of the C2-C5 env gene sequences of the replicating HIV-1 was performed in sequential samples collected over a 3–5 year period; overall, 301 HIV-1 genomic RNA sequences were amplified… CONTINUE READING
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