Dynamic expression patterns of Robo (Robo1 and Robo2) in the developing murine central nervous system.

@article{Sundaresan2004DynamicEP,
  title={Dynamic expression patterns of Robo (Robo1 and Robo2) in the developing murine central nervous system.},
  author={Vasi Sundaresan and Elvira T Mambetisaeva and William D Andrews and Adelaide Annan and Bernd Kn{\"o}ll and Guy Tear and Lawrence Howard Bannister},
  journal={The Journal of comparative neurology},
  year={2004},
  volume={468 4},
  pages={467-81}
}
The Robo family of molecules is important for axon guidance across the midline during central nervous system (CNS) development in invertebrates and vertebrates. Here we describe the patterns of Robo protein expression in the developing mouse CNS from embryonic day (E) 9.5 to postnatal day (P) 4, as determined by immunohistochemical labeling with an antibody (S3) raised against a common epitope present in the Robo ectodomain of Robos 1 and 2. In the spinal cord, midline-crossing axons are… CONTINUE READING