Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS.

@article{Zhang2006DynamicEO,
  title={Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS.},
  author={Jiasheng Zhang and Eric H. Huang},
  journal={Journal of neurobiology},
  year={2006},
  volume={66 8},
  pages={
          882-95
        }
}
Neurotrophic factors support the survival of spinal motoneurons (MNs) and have been considered as strong candidates for treating motoneuron diseases. However, it is unclear if the right combination of neurotrophic factor receptors is present in postnatal spinal MNs. In this study, we show that the level of c-ret expression remains relatively stable in embryonic and postnatal spinal MNs. In contrast, the mRNA and protein of GFRalpha1 and -2 are progressively down-regulated in postnatal life. By… CONTINUE READING
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