Dynamic expression and essential functions of Hes7 in somite segmentation.

  title={Dynamic expression and essential functions of Hes7 in somite segmentation.},
  author={Yasumasa Bessho and Ryuzo Sakata and Setsuko Komatsu and Kohei Shiota and Shuhei Yamada and Ryoichiro Kageyama},
  journal={Genes & development},
  volume={15 20},
The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7-null mice, somites are not properly segmented and their anterior-posterior polarity is disrupted. As a result, the somite derivatives such as vertebrae and ribs are severely disorganized. Although expression of Notch and its ligands is not affected significantly, the oscillator and… CONTINUE READING
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