Dynamic evolution of clonal epialleles revealed by methclone

  title={Dynamic evolution of clonal epialleles revealed by methclone},
  author={Sheng Li and Francine E. Garrett-Bakelman and Alexander Perl and Selina M. Luger and Chao Zhang and Bik L. To and Ian D. Lewis and Anna L. Brown and Richard J. D’Andrea and Margaret Elizabeth Ross and Ross L. Levine and Martin P Carroll and Ari Melnick and Christopher E. Mason},
  booktitle={Genome Biology},
We describe methclone, a novel method to identify epigenetic loci that harbor large changes in the clonality of their epialleles (epigenetic alleles). Methclone efficiently analyzes genome-wide DNA methylation sequencing data. We quantify the changes using a composition entropy difference calculation and also introduce a new measure of global clonality shift, loci with epiallele shift per million loci covered, which enables comparisons between different samples to gauge overall epiallelic… CONTINUE READING