Dynamic evaluation of fluid shifts during normothermic and hypothermic cardiopulmonary bypass in piglets

  title={Dynamic evaluation of fluid shifts during normothermic and hypothermic cardiopulmonary bypass in piglets},
  author={Jon Kenneth Heltne and M E Koller and T. Lund and Joel L. Bert and Stein Erik Rynning and Lodve B Stangeland and Paul Husby},
  journal={Acta Anaesthesiologica Scandinavica},
Background: Edema, generalized overhydration and organ dysfunction commonly occur in patients undergoing open‐heart surgery using cardiopulmonary bypass (CPB) and induced hypothermia. Activation of inflammatory reactions induced by contact between blood and foreign surfaces are commonly held responsible for the disturbances of fluid balance (“capillary leak syndrome”). We used an online technique to determine fluid shifts between the intravascular and the interstitial space during normothermic… 
Studies on fluid extravasation related to induced hypothermia during cardiopulmonary bypass in piglets
The aim of the present study was to characterize the distribution of the fluid given to maintain normovolemia and investigate the quantity and quality of the liquid extravasated during hypothermic compared to normothermic CPB.
Temperature‐related fluid extravasation during cardiopulmonary bypass: An analysis of filtration coefficients and transcapillary pressures
The purpose of this work is to improve the understanding of fluid pathophysiology and to explore the implications of the changes in determinants of transcapillary fluid exchange during CPB with and without hypothermia.
Fluid extravasation during cardiopulmonary bypass in piglets – effects of hypothermia and different cooling protocols
It is evaluated how hypothermia and different cooling strategies influenced the fluid extravasation rate during CPB.
Low arterial pressure during cardiopulmonary bypass in piglets does not decrease fluid leakage
This study assessed whether lowering of the mean arterial pressure and/or the central venous pressure could reduce fluid extravasation during normothermic and hypothermic CPB.
Fluid distribution kinetics during cardiopulmonary bypass
The distribution half-time of Ringer's solution during isovolumetric cardiopulmonary bypass was 8 minutes, which is the same as for crystalloid fluid infusions in healthy subjects, and the intravascular albumin mass increased.
Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs
In hypothermic-isolated blood-perfused rat lungs perfused at constant flow, fluid filtration coefficient per gram PLW and B/P ratio increased more than 10-fold concerted by increased hemoconcentration, but the changes were less inHypothermic lungs perfusion at constant PPA.
Hemodilution During Cardiopulmonary Bypass Increases Cerebral Infarct Volume After Middle Cerebral Artery Occlusion in Rats
In this experimental model of CPB with reversible MCAO-induced focal cerebral ischemia, hemodilution worsened neurological function and increased cerebral infarct volume.
Comparison of Early Outcomes for Normothermic and Hypothermic Cardiopulmonary Bypass in Children Undergoing Congenital Heart Surgery
N-CPB may reduce inotropic and respiratory support, shorten PICU stay, increase peri costs to peri-operative costs, validate and support transfusion and platelets, and reduce the cost of transfusions after surgery.


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It is concluded that midazolam, fentanyl and isoflurane provide cardiovascular stability including normal microvascular fluid exchange, which are essential elements for securing the quality of results obtained during cardiovascular research in anaesthetized pigs.
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A significant increase in catecholamines could jeopardize myocardial protective measures during CPB, and the predominant humoral response to CPB appears to be adrenomedullary release of E.