Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore.

@article{Richerson2003DynamicEO,
  title={Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore.},
  author={George B Richerson and Yuanming Wu},
  journal={Journal of neurophysiology},
  year={2003},
  volume={90 3},
  pages={1363-74}
}
Many electrophysiologists view neurotransmitter transporters as tiny vacuum cleaners, operating continuously to lower extracellular neurotransmitter concentration to zero. However, this is not consistent with their known behavior, instead only reducing extracellular neurotransmitter concentration to a finite, nonzero value at which an equilibrium is reached. In addition, transporters are equally able to go in either the forward or reverse direction, and when they reverse, they release their… CONTINUE READING
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