Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter.

@article{Borre2002DynamicEB,
  title={Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter.},
  author={Lars Borre and Michael P. Kavanaugh and Baruch I. Kanner},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 16},
  pages={13501-7}
}
In the brain, the neurotransmitter glutamate is removed from the synaptic cleft by (Na(+) + K(+))-coupled transporters by an electrogenic process. Moreover, these transporters mediate a sodium- and glutamate-dependent uncoupled chloride conductance. In contrast to the wild type, the uptake of radiolabeled substrate by the I421C mutant is inhibited by the membrane-impermeant [2-(trimethylammonium)ethyl]methanethiosulfonate and also by other sulfhydryl reagents. In the wild-type and the… CONTINUE READING

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