Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering.

@article{Venditti2015DynamicEB,
  title={Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering.},
  author={Vincenzo Venditti and Charles D. Schwieters and Alexander Grishaev and G Marius Clore},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 37},
  pages={11565-70}
}
Enzyme I (EI) is the first component in the bacterial phosphotransferase system, a signal transduction pathway in which phosphoryl transfer through a series of bimolecular protein-protein interactions is coupled to sugar transport across the membrane. EI is a multidomain, 128-kDa homodimer that has been shown to exist in two conformational states related to one another by two large (50-90°) rigid body domain reorientations. The open conformation of apo EI allows phosphoryl transfer from His189… CONTINUE READING
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