Dynamic epistasis for different alleles of the same gene

@article{Xu2012DynamicEF,
  title={Dynamic epistasis for different alleles of the same gene},
  author={Lin Xu and Brandon Barker and Zhenglong Gu},
  journal={Proceedings of the National Academy of Sciences},
  year={2012},
  volume={109},
  pages={10420 - 10425}
}
  • Lin Xu, B. Barker, Z. Gu
  • Published 11 June 2012
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
Epistasis refers to the phenomenon in which phenotypic consequences caused by mutation of one gene depend on one or more mutations at another gene. Epistasis is critical for understanding many genetic and evolutionary processes, including pathway organization, evolution of sexual reproduction, mutational load, ploidy, genomic complexity, speciation, and the origin of life. Nevertheless, current understandings for the genome-wide distribution of epistasis are mostly inferred from interactions… Expand
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