Dynamic epigenomic landscapes during early lineage specification in mouse embryos

@article{Zhang2017DynamicEL,
  title={Dynamic epigenomic landscapes during early lineage specification in mouse embryos},
  author={Yu Zhang and Yunlong Xiang and Qiangzong Yin and Zhenhai Du and Xu Peng and Qiujun Wang and Miguel Fidalgo and Weikun Xia and Yuanyuan Li and Zhenao Zhao and Wenhao Zhang and Jing Sheng Ma and Feng Xu and Jianlong Wang and Lei Thor Li and Wei Xie},
  journal={Nature Genetics},
  year={2017},
  volume={50},
  pages={96-105}
}
In mammals, all somatic development originates from lineage segregation in early embryos. However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell fate commitment remains poorly characterized. Here we report a comprehensive investigation of transcriptomes and base-resolution methylomes for early lineages in peri- and postimplantation mouse embryos. We found allele-specific and lineage-specific de novo methylation at CG and CH sites that led to differential… CONTINUE READING