Dynamic effect of di-2-(ethylhexyl) phthalate on testicular toxicity: epigenetic changes and their impact on gene expression.

@article{Wu2010DynamicEO,
  title={Dynamic effect of di-2-(ethylhexyl) phthalate on testicular toxicity: epigenetic changes and their impact on gene expression.},
  author={Shengde Wu and Jing Zhu and Yasha Li and Tao Lin and Liqiang Gan and Xingang Yuan and Mingdeng Xu and Guanghui Wei},
  journal={International journal of toxicology},
  year={2010},
  volume={29 2},
  pages={193-200}
}
This study investigated epigenetic (specifically, DNA methylation) changes and their impact on gene expression in testes induced by maternal exposure to Di-2-(ethylhexyl) phthalate (DEHP) in mice. Testicular dysgenesis syndrome was induced in fetuses and pups by maternal exposure to DEHP at 500 mg/kg/d, and testes were excised for analysis on gestation day (GD) 19 and postnatal days (PNDs) 3, 21, 56, and 90. High-performance liquid chromatography (HPLC) was performed to analyze DNA methylation… CONTINUE READING

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