Dynamic differential regulation of innate immune transcripts during the infection of alveolar macrophages by the porcine reproductive and respiratory syndrome virus.

@article{AitAli2008DynamicDR,
  title={Dynamic differential regulation of innate immune transcripts during the infection of alveolar macrophages by the porcine reproductive and respiratory syndrome virus.},
  author={Tahar Ait-Ali and Alison D. Wilson and David G. Westcott and J P Frossard and Marnie A. Mellencamp and Trevor W. Drew and Stephen Bishop and Alan L. Archibald},
  journal={Developments in biologicals},
  year={2008},
  volume={132},
  pages={239-45}
}
Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, is the etiologic agent of an infectious disease of that name, characterized by respiratory disorders, abortion in pregnant sows and high mortality in piglets, resulting in significant economic losses in the pig industry worldwide. In order to identify whether genetic differences in PRRSV response may exist in pigs, alveolar macrophages were used to assess the progression of the type-I interferon (IFN) transcript… CONTINUE READING