Dynamic detection of a single bacterium: nonlinear rotation rate shifts of driven magnetic microsphere stages
@article{McNaughton2006DynamicDO,
title={Dynamic detection of a single bacterium: nonlinear rotation rate shifts of driven magnetic microsphere stages},
author={Brandon H. McNaughton and Rodney R. Agayan and Raoul Kopelman},
journal={arXiv: Biological Physics},
year={2006}
}We report on a new technique which was used to detect single Escherichia coli that is based on the changes in the nonlinear rotation of a magnetic microsphere driven by an external magnetic field. The presence of one Escherichia Coli bacterium on the surface of a 2.0 micron magnetic microsphere caused an easily measurable change in the drag of the system and, therefore, in the nonlinear rotation rate. The straight-forward measurement uses standard microscopy techniques and the observed average…