Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors.

@article{Bunyapaiboonsri2001DynamicDO,
  title={Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors.},
  author={Taridaporn Bunyapaiboonsri and Olof Ramstr{\"o}m and Sophie Lohmann and Jean-Marie Lehn and Ling Peng and Maurice Goeldner},
  journal={Chembiochem : a European journal of chemical biology},
  year={2001},
  volume={2 6},
  pages={438-44}
}
A dynamic combinatorial library composed of interconverting acylhydrazones has been generated and screened towards inhibition of acetylcholinesterase from the electric ray Torpedo marmorata. Starting from a small set (13) of initial hydrazide and aldehyde building blocks, a library containing possibly 66 different species was obtained in a single operation. Of all possible acylhydrazones formed, active compounds containing two terminal cationic recognition groups separated by an appropriate… CONTINUE READING