Dynamic correlations between hemodynamic, metabolic, and neuronal responses to acute whole-brain ischemia.

@article{Taylor2015DynamicCB,
  title={Dynamic correlations between hemodynamic, metabolic, and neuronal responses to acute whole-brain ischemia.},
  author={Jennifer M Taylor and Xiao-Hong Zhu and Yi Zhang and Wei Hua Chen},
  journal={NMR in biomedicine},
  year={2015},
  volume={28 11},
  pages={1357-65}
}
Cerebral ischemia sets off a cascade of neuronal and metabolic responses to preserve brain viability. An understanding of the temporal evolution of these changes during and after ischemia, and their correlation with hemodynamic changes, is essential. In this study, a 12-min whole-brain ischemia based on the four-blood-vessel occlusion model was employed in rats. Using a high-temporal-resolution simultaneous (1)H-(31)P MRS acquisition sequence at 9.4 T, we investigated dynamic occlusion and… CONTINUE READING