Dynamic control of type I IFN signalling by an integrated network of negative regulators.

@article{Porritt2015DynamicCO,
  title={Dynamic control of type I IFN signalling by an integrated network of negative regulators.},
  author={Rebecca A Porritt and Paul J. Hertzog},
  journal={Trends in immunology},
  year={2015},
  volume={36 3},
  pages={150-60}
}
Whereas type I interferons (IFNs) have critical roles in protection from pathogens, excessive IFN responses contribute to pathology in both acute and chronic settings, pointing to the importance of balancing activating signals with regulatory mechanisms that appropriately tune the response. Here we review evidence for an integrated network of negative regulators of IFN production and action, which function at all levels of the activating and effector signalling pathways. We propose that the aim… CONTINUE READING
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