Dynamic control of maximal ventricular elastance via the baroreflex and force-frequency relation in awake dogs before and after pacing-induced heart failure.

@article{Chen2010DynamicCO,
  title={Dynamic control of maximal ventricular elastance via the baroreflex and force-frequency relation in awake dogs before and after pacing-induced heart failure.},
  author={Xiaoxiao Chen and Javier A. Sala-Mercado and Robert L. Hammond and Masashi J Ichinose and Soroor Soltani and Ramakrishna Mukkamala and Donal S. O'Leary},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 1},
  pages={H62-9}
}
We investigated to what extent maximal ventricular elastance (E(max)) is dynamically controlled by the arterial baroreflex and force-frequency relation in conscious dogs and to what extent these mechanisms are attenuated after the induction of heart failure (HF). We mathematically analyzed spontaneous beat-to-beat hemodynamic variability. First, we estimated E(max) for each beat during a baseline period using the ventricular unstressed volume determined with the traditional multiple beat method… CONTINUE READING
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