Dynamic contrast-enhanced ultrasonography (DCE-US) with quantification of tumor perfusion: a new diagnostic tool to evaluate the early effects of antiangiogenic treatment

@article{Lassau2007DynamicCU,
  title={Dynamic contrast-enhanced ultrasonography (DCE-US) with quantification of tumor perfusion: a new diagnostic tool to evaluate the early effects of antiangiogenic treatment},
  author={Nathalie Lassau and Linda Chami and Baya Benatsou and Pierre Peronneau and Alain Roche},
  journal={European Radiology Supplements},
  year={2007},
  volume={17},
  pages={89-98}
}
Dynamic contrast-enhanced ultrasonography (DCEUS) using the contrast agent Sonovue and vascular recognition imaging software is a novel technique that enables the detection of microvessels and quantitative assessment of solid tumor perfusion using raw linear data. Clinical trials have shown that DCE-US can be used to assess the anticancer efficacy of antiangiogenic treatment, for which conventional efficacy criteria based on size are unsuitable. Reduction in tumor vascularization can easily be… 
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Standardization of Dynamic Contrast-Enhanced Ultrasound for the Evaluation of Antiangiogenic Therapies: The French Multicenter Support for Innovative and Expensive Techniques Study
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The standardization and dissemination of dynamic contrast-enhanced ultrasound (DCE-US) for the evaluation of antiangiogenic treatments in solid tumors across 19 oncology centers in France is described and a quality score is defined to account for the variability of the evaluation criteria used to collect DCE- US data.
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The principles and potential clinical applications of CEUS in determining tumor response and its promising role in enhancing medication delivery in certain tumors are discussed.
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Dynamic contrast-enhanced ultrasound is a new functional imaging technique that provides a validated criterion, namely, the change of AUC from baseline to day 30, which is predictive of tumor progression in a large multicenter cohort.
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Early response of transcatheter arterial chemoembolization for hepatocellular carcinoma (HCC) is evaluated by quantitative analysis of intratumoral vascularity with CE-US in three patients by quantitatively indicating the early response of HCC to TACE.
Perfusion CT and US of colorectal cancer liver metastases: a correlative study of two dynamic imaging modalities.
Advanced hepatocellular carcinoma: early evaluation of response to bevacizumab therapy at dynamic contrast-enhanced US with quantification--preliminary results.
TLDR
Dynamic US can be used to quantify dynamic changes in tumor vascularity as early as 3 days after bevacizumab administration in patients with HCC, and they may be potential surrogate measures of the effectiveness of antiangiogenic therapy in patientsWith HCC.
Perfusion CT and US of colorectal liver metastases : a correlative study of two dynamic imaging modalities
TLDR
DCE-US-based slope-value and tumour-to-liver perfusion gradient correlate best with DCE-CT perfusion values, however, both techniques cannot be used interchangeably.
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DCE-MRI, -CT and ultrasound produce complementary parameters that reflect the prognosis of patients receiving sunitinib for mRCC, and baseline vascular heterogeneity by DCE-US has the strongest prognostic value for PFS.
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The sharpened analysis of CEUS pixel intensity presented here strengthened the monitoring of breast tumor vasculature with the potential to improve the prediction of docetaxel efficacy.
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The advent of CEUS has greatly enhanced the usefulness of US and even changed the status of US in clinical practice, and it is expected that its use will be expanded further in the future.
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