Dynamic conformational model for the role of ITS2 in pre-rRNA processing in yeast.

@article{Ct2002DynamicCM,
  title={Dynamic conformational model for the role of ITS2 in pre-rRNA processing in yeast.},
  author={Colette A C{\^o}t{\'e} and Chris L Greer and Brenda A. Peculis},
  journal={RNA},
  year={2002},
  volume={8 6},
  pages={786-97}
}
Maturation of the large subunit rRNAs includes a series of cleavages that result in removal of the internal transcribed spacer (ITS2) that separates mature 5.8S and 25/28S rRNAs. Previous work demonstrated that formation of higher order secondary structure within the assembling pre-ribosomal particle is a prerequisite for accurate and efficient pre-rRNA… CONTINUE READING